Hallo,
We hebben er al een hele weg op zitten, met 12 miskramen, een doodgeboren dochter na voldragen zwangerschap en gelukkig ook een bengeltje.
Chronologisch waren dat dus 2 mk, ons doodgeboren dochter, 2 mk, een bengeltje en daarna terug 8 miskramen.
We hebben via onze gyn verschillende testen achter de rug, genetische testen, stolling, ... Waar niets uitkwam.
Uiteindelijk (begin december)dan toch de knoop doorgehakt om naar fertiliteit te stappen.
De meeste onderzoeken waren al gebeurd, dus buiten nog een paar bloedtesten en een uitstrijkje/kweekje kon er niet meer gedaan worden.
Eind januari kreeg ik dan de uitslag.
Er werd aangeraden om een baarmoederfoto te nemen en ik bleek een vaginale bacterie te hebben, ureaplasma urealytisch genaamd. Tegen die bacterie moesten zowel mijn echtgenoot als ik een antibioticakuur van 10 dagen nemen en dan moest ik een controlekweekje laten nemen om te kijken of de bacterie weg was.
Ik besloot om met de baarmoederfoto te wachten en eerste die kuur te nemen en nog een half jaar te proberen om een zwangerschap in stand te houden.
Ik kreeg de uitslag vlak na mijn laatste miskraam, heb direct daarna de kuur genomen en heb toen een tussentijdse bloeding gehad. menstruatie heb ik niet meer gezien en ben nu ondertussen 19 weken zwanger!
Blijkbaar was dus inderdaad die bacterie de oorzaak van al (of toch van een groot deel)mijn miskramen!
Blijkbaar is dit nog niet zo lang geleden ontdekt.
Van een vriendin kreeg ik wetenschappelijke teksten vast van januari van dit jaar waarin staat dat deze bacterie vroeggeboorte en herhaalde miskramen in de hand werkt. Mijn miskramen waren allemaal voor de 12 weken, ik ben dus bij de 'gelukkigen' die er 'maar' een miskraam van kregen, voor hetzelfde geld had ik kinderen verloren door vroeggeboorte ...
Ik wilde jullei mijn verhaal delen, om een hart onder de riem te steken bij degene die met herhaalde miskramen zitten en om die stomme bacterie wat meer bekendheid te geven. Ik raad aan om aan de gyn zeker te vragen om te testen op deze bacterie als je met herhaalde miskramen zit.
Ik zal de teksten die ik doorkreeg hieronder ook kopieren.
Succes allemaal!
Bacterie oorzaak van herhaalde miskramen
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WitteVM
- Berichten: 7
- Lid geworden op: 11 februari 2007, 10:24
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WitteVM
- Berichten: 7
- Lid geworden op: 11 februari 2007, 10:24
Imudia AN, Detti L, Puscheck EE, Yelian FD, Diamond MP.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, 3750 Woodward Avenue, Suite 200-D, Detroit, MI, 48201, USA.
1: J Assist Reprod Genet. 2008 Jan;25(1):43-6. Epub 2008 Jan 18 (DUS:HEEL RECENT ARTIKEL!!)
PURPOSE: To determine the prevalence of positive test for Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) infections, and their corresponding Rubella status when undergoing workup for infertility. METHODS: Retrospective chart review to determine infection status for UU, MH, CT, and NG as determined by cervical swab, as well as the serum Rubella antibody titer. RESULTS: A total of 46 patients of the patients reviewed were positive for UU (20.1%), three patients were positive for MH (1.3%), five patients were positive for CT (2.2%) and one patient was positive for NG (0.4%). Rubella immunity was confirmed in 90.3% of patients. CONCLUSION: Approximately one quarter of women presenting to an infertility clinic seeking to conceive were found to have a positive test for UU, MH, CT or NG infection. Additionally, almost 10% of the patients were Rubella non-immune at the time of presentation for infertility evaluation.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, 3750 Woodward Avenue, Suite 200-D, Detroit, MI, 48201, USA.
1: J Assist Reprod Genet. 2008 Jan;25(1):43-6. Epub 2008 Jan 18 (DUS:HEEL RECENT ARTIKEL!!)
PURPOSE: To determine the prevalence of positive test for Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) infections, and their corresponding Rubella status when undergoing workup for infertility. METHODS: Retrospective chart review to determine infection status for UU, MH, CT, and NG as determined by cervical swab, as well as the serum Rubella antibody titer. RESULTS: A total of 46 patients of the patients reviewed were positive for UU (20.1%), three patients were positive for MH (1.3%), five patients were positive for CT (2.2%) and one patient was positive for NG (0.4%). Rubella immunity was confirmed in 90.3% of patients. CONCLUSION: Approximately one quarter of women presenting to an infertility clinic seeking to conceive were found to have a positive test for UU, MH, CT or NG infection. Additionally, almost 10% of the patients were Rubella non-immune at the time of presentation for infertility evaluation.
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WitteVM
- Berichten: 7
- Lid geworden op: 11 februari 2007, 10:24
Am J Obstet Gynecol. 2008 Jan;198(1):110.e1-7.
Detection of bacteria in placental tissues obtained from extremely low gestational age neonates.
Onderdonk AB, Delaney ML, DuBois AM, Allred EN, Leviton A; Extremely Low Gestational Age Newborns (ELGAN) Study Investigators.
Harvard Medical School and the Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
OBJECTIVE: The objective of the study was to quantify and identify aerobic and anaerobic bacteria as well as Mycoplasma and Ureaplasma in the chorionic parenchyma. STUDY DESIGN: A sample of the chorionic parenchyma from neonates delivered between 23-27 completed weeks was cultured and tested by polymerase chain reaction (PCR) methods using universal bacterial primers for the presence of bacteria and mycoplasmas. RESULTS: The culture positive rate was higher for vaginal deliveries (333/489; 68%) than for cesarean sections (363/876; 41%). Thirty percent of all culture-positive samples had only aerobic bacteria, 21% of the samples had only anaerobic bacteria, and 9% of the samples had only Mycoplasma/Ureaplasma. The mean concentration of Mycoplasma/Ureaplasma (4.00 +/- 1.11 log10 CFU/g) was significantly higher (P < .001) than the total count of either aerobes (3.24 +/- 1.12 log10 CFU/g) or anaerobes (2.89 +/- 0.99 log10 CFU/g). Staphylococcus sp. and Corynebacterium sp. as well as organisms associated with bacterial vaginosis were the most frequently recovered. A PCR product was not detected from either randomly selected or known culture-positive samples. CONCLUSION: Approximately half of second-trimester placentas harbor organisms within the chorionic plate. The chorion parenchyma appears to harbor constituents that prevent the identification of bacterial deoxyribonucleic acid by PCR methods.
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Pediatr Dev Pathol. 2008 Jan 1;11(1):15-22.
Characterization of Chorioamnionitis in 2nd-Trimester C-Section Placentas and Correlation with Microorganism Recovery from Subamniotic Tissues.
Hecht JL, Onderdonk A, Delaney M, Allred EN, Kliman HJ, Zambrano E, Pflueger SM, Livasy CA, Bhan I, Leviton A; for the ELGAN study investigators.
Prolonged exposure to infection appears to influence fetal/neonatal development. We characterize the relationship between histologic patterns of inflammation and microorganism recovery from the placentas of live born infants delivered before the 28th postmenstrual week. The subamniotic parenchyma of 835 placentas delivered by cesarean section were cultured and evaluated for specific histologic patterns of inflammation in a blinded fashion. Cases with prolonged membrane rupture were excluded. Microorganisms were recovered from 41% of placentas. Microorganisms found more frequently in placentas with high-grade chorionic plate inflammation include Actinomyces, Prevotella bivia, Corynebacterium sp., Escherichia coli, Peptostreptococcus magnus, multiple species of Streptococci, and Mycoplasma sp., including Ureaplasma urealyticum. These microorganisms were also associated with fetal vasculitis (neutrophilic infiltration of chorionic plate stem vessels or umbilical cord). Recovery of microorganisms from placental parenchyma is associated with histologic inflammation. The same microorganisms responsible for inciting high-grade chorionic plate inflammation are also most likely to promote fetal inflammation.
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Am J Obstet Gynecol. 2008 Jan;198(1):43.e1-5.
Comment in Am J Obstet Gynecol. 2008 Jan;198(1):1-3.
The Alabama Preterm Birth Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants.
Goldenberg RL, Andrews WW, Goepfert AR, Faye-Petersen O, Cliver SP, Carlo WA, Hauth JC.
Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA, USA.
OBJECTIVE: This study was undertaken to evaluate the frequency of umbilical cord blood infections with Ureaplasma urealyticum and Mycoplasma hominis in preterm 23- to 32-week births and to determine their association with various obstetric conditions, markers of placental inflammation, and newborn outcomes. STUDY DESIGN: 351 mother/infant dyads with deliveries between 23 and 32 weeks' gestational age who had cord blood cultures for U. urealyticum and M. hominis had their medical records abstracted, other placental cultures performed, cord interleukin-6 levels determined, placentas evaluated histologically, and infant outcomes determined. RESULTS: U. urealyticum and/or M. hominis were present in 23% of cord blood cultures. Positive cultures were more common in infants of nonwhite women (27.9% vs 16.8%; P = .016), in women less than 20 years of age, in those undergoing a spontaneous compared to an indicated preterm delivery (34.7% vs 3.2%; P = .0001), and in those delivering at earlier gestational ages. Intrauterine infection and inflammation were more common among infants with a positive U. urealyticum and M. hominis culture as evidenced by placental cultures for these and other bacteria, elevated cord blood interleukin-6 levels, and placental histology. Infants with positive cord blood U. urealyticum and M. hominis cultures were more likely to have neonatal systemic inflammatory response syndrome (41.3% vs 25.7%; P = .007; adjusted odds ratio, 1.86; 1.08-3.21) and probably bronchopulmonary dysplasia (26.8% vs 10.1%; P = .0001; adjusted odds ratio 1.99; 0.91-4.37), but were not significantly different for other neonatal outcomes, including respiratory distress syndrome, intraventricular hemorrhage, or death. CONCLUSION: U. urealyticum and M. hominis cord blood infections are far more common in spontaneous vs indicated preterm deliveries and are strongly associated with markers of acute placental inflammation. Positive cultures are associated with neonatal systemic inflammatory response syndrome and probably bronchopulmonary dysplasia.
-----------
Detection of bacteria in placental tissues obtained from extremely low gestational age neonates.
Onderdonk AB, Delaney ML, DuBois AM, Allred EN, Leviton A; Extremely Low Gestational Age Newborns (ELGAN) Study Investigators.
Harvard Medical School and the Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
OBJECTIVE: The objective of the study was to quantify and identify aerobic and anaerobic bacteria as well as Mycoplasma and Ureaplasma in the chorionic parenchyma. STUDY DESIGN: A sample of the chorionic parenchyma from neonates delivered between 23-27 completed weeks was cultured and tested by polymerase chain reaction (PCR) methods using universal bacterial primers for the presence of bacteria and mycoplasmas. RESULTS: The culture positive rate was higher for vaginal deliveries (333/489; 68%) than for cesarean sections (363/876; 41%). Thirty percent of all culture-positive samples had only aerobic bacteria, 21% of the samples had only anaerobic bacteria, and 9% of the samples had only Mycoplasma/Ureaplasma. The mean concentration of Mycoplasma/Ureaplasma (4.00 +/- 1.11 log10 CFU/g) was significantly higher (P < .001) than the total count of either aerobes (3.24 +/- 1.12 log10 CFU/g) or anaerobes (2.89 +/- 0.99 log10 CFU/g). Staphylococcus sp. and Corynebacterium sp. as well as organisms associated with bacterial vaginosis were the most frequently recovered. A PCR product was not detected from either randomly selected or known culture-positive samples. CONCLUSION: Approximately half of second-trimester placentas harbor organisms within the chorionic plate. The chorion parenchyma appears to harbor constituents that prevent the identification of bacterial deoxyribonucleic acid by PCR methods.
-------
Pediatr Dev Pathol. 2008 Jan 1;11(1):15-22.
Characterization of Chorioamnionitis in 2nd-Trimester C-Section Placentas and Correlation with Microorganism Recovery from Subamniotic Tissues.
Hecht JL, Onderdonk A, Delaney M, Allred EN, Kliman HJ, Zambrano E, Pflueger SM, Livasy CA, Bhan I, Leviton A; for the ELGAN study investigators.
Prolonged exposure to infection appears to influence fetal/neonatal development. We characterize the relationship between histologic patterns of inflammation and microorganism recovery from the placentas of live born infants delivered before the 28th postmenstrual week. The subamniotic parenchyma of 835 placentas delivered by cesarean section were cultured and evaluated for specific histologic patterns of inflammation in a blinded fashion. Cases with prolonged membrane rupture were excluded. Microorganisms were recovered from 41% of placentas. Microorganisms found more frequently in placentas with high-grade chorionic plate inflammation include Actinomyces, Prevotella bivia, Corynebacterium sp., Escherichia coli, Peptostreptococcus magnus, multiple species of Streptococci, and Mycoplasma sp., including Ureaplasma urealyticum. These microorganisms were also associated with fetal vasculitis (neutrophilic infiltration of chorionic plate stem vessels or umbilical cord). Recovery of microorganisms from placental parenchyma is associated with histologic inflammation. The same microorganisms responsible for inciting high-grade chorionic plate inflammation are also most likely to promote fetal inflammation.
-------------
Am J Obstet Gynecol. 2008 Jan;198(1):43.e1-5.
Comment in Am J Obstet Gynecol. 2008 Jan;198(1):1-3.
The Alabama Preterm Birth Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants.
Goldenberg RL, Andrews WW, Goepfert AR, Faye-Petersen O, Cliver SP, Carlo WA, Hauth JC.
Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA, USA.
OBJECTIVE: This study was undertaken to evaluate the frequency of umbilical cord blood infections with Ureaplasma urealyticum and Mycoplasma hominis in preterm 23- to 32-week births and to determine their association with various obstetric conditions, markers of placental inflammation, and newborn outcomes. STUDY DESIGN: 351 mother/infant dyads with deliveries between 23 and 32 weeks' gestational age who had cord blood cultures for U. urealyticum and M. hominis had their medical records abstracted, other placental cultures performed, cord interleukin-6 levels determined, placentas evaluated histologically, and infant outcomes determined. RESULTS: U. urealyticum and/or M. hominis were present in 23% of cord blood cultures. Positive cultures were more common in infants of nonwhite women (27.9% vs 16.8%; P = .016), in women less than 20 years of age, in those undergoing a spontaneous compared to an indicated preterm delivery (34.7% vs 3.2%; P = .0001), and in those delivering at earlier gestational ages. Intrauterine infection and inflammation were more common among infants with a positive U. urealyticum and M. hominis culture as evidenced by placental cultures for these and other bacteria, elevated cord blood interleukin-6 levels, and placental histology. Infants with positive cord blood U. urealyticum and M. hominis cultures were more likely to have neonatal systemic inflammatory response syndrome (41.3% vs 25.7%; P = .007; adjusted odds ratio, 1.86; 1.08-3.21) and probably bronchopulmonary dysplasia (26.8% vs 10.1%; P = .0001; adjusted odds ratio 1.99; 0.91-4.37), but were not significantly different for other neonatal outcomes, including respiratory distress syndrome, intraventricular hemorrhage, or death. CONCLUSION: U. urealyticum and M. hominis cord blood infections are far more common in spontaneous vs indicated preterm deliveries and are strongly associated with markers of acute placental inflammation. Positive cultures are associated with neonatal systemic inflammatory response syndrome and probably bronchopulmonary dysplasia.
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-
Mom to be
- Berichten: 160
- Lid geworden op: 20 mei 2008, 10:49
Bedankt om ons deze tip te geven. Het is ergens spijtig dat je nu pas weet wat er scheelde, want tentslotte ging het om iets waar je met een simpele antibioticakuur vanaf bent geraakt. Langs de andere kant: super dat het ontdekt hebben, zie het fantastisch resultaat dat je hebt: 19 weken zwanger! 
Dit is een website waar we elkaar allemaal zo goed en kwaad mogelijk proberen te helpen en jij bent het ultieme bewijs van hoe belangrijk het is om info te delen ..
Dit is een website waar we elkaar allemaal zo goed en kwaad mogelijk proberen te helpen en jij bent het ultieme bewijs van hoe belangrijk het is om info te delen ..
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annemarie grove
- Berichten: 1
- Lid geworden op: 20 oktober 2009, 22:58
Hoi,
Ik ben nieuw hier dus weet niet of ik nu goed doe.maar ik wil een vraag stellen over het onderwerp Bacterie oorzaak van herhaalde miskramen.
Ik heb 3 miskramen gehad en ben er vandaag achter gekomen dat ik al een tijd de staphylococcus aureus bacterie bij me draag. Is dit ook de bacterie waar jullie het over hebben?
Ik zit dit trillend te typen. Hoop dat ik snel antwoord krijg.
Groetjes, Annemarie
Ik ben nieuw hier dus weet niet of ik nu goed doe.maar ik wil een vraag stellen over het onderwerp Bacterie oorzaak van herhaalde miskramen.
Ik heb 3 miskramen gehad en ben er vandaag achter gekomen dat ik al een tijd de staphylococcus aureus bacterie bij me draag. Is dit ook de bacterie waar jullie het over hebben?
Ik zit dit trillend te typen. Hoop dat ik snel antwoord krijg.
Groetjes, Annemarie
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kathleenchris
- Berichten: 371
- Lid geworden op: 8 februari 2007, 10:59
Hallo meid,
Het is heel moeilijk om hierover een uitspraak over te doen weet je?
Ondertussen hebben we een hele zoekperiode achter de rug ivm infecties. En voor onze bacterie hebben we een aanpak nu, maar deze kan niet doorgetrokken worden naar alle bacteriën. Kan je het bespreken met je gyn? Staat hij hiervoor open? Krijg je voldoende feedback?
Heel veel succes meid, en weet dat je er niet alleen voor staat !!!
kathleen
Het is heel moeilijk om hierover een uitspraak over te doen weet je?
Ondertussen hebben we een hele zoekperiode achter de rug ivm infecties. En voor onze bacterie hebben we een aanpak nu, maar deze kan niet doorgetrokken worden naar alle bacteriën. Kan je het bespreken met je gyn? Staat hij hiervoor open? Krijg je voldoende feedback?
Heel veel succes meid, en weet dat je er niet alleen voor staat !!!
kathleen
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